E kūʻai iā K-41 ma ka pūnaewele

Hōʻike o ka huahana

ʻO K-41 kahi polyether monoglucoside fungal metabolite i hoʻokaʻawale ʻia mai ka S. hygroscopicus me ka hana antibiotic a me ka antiparasitic.¹,² He ʻeleu ia i ka B. subtilis, B. anthracis, S. aureus, S. pyogenes, S. pneumoniae, C.

diphtheriae a me M. tuberculosis (MIC = 3,13; 1,56; 1,56; 0,78; 0,39; 0,78 a me 3,13 µg/ml).

¹ He ikaika ka K-41 e kū'ē i nā kānana P. falciparum pale-K1 a me ka FCR3 (IC50 = 8,5 a me 31 nM, pakahi).²

In vivo, K-41 he antiparasitic hana i loko o ka iole kükohu o P. berghei a me P. yoelii maʻi (ED50 = 1,9 a me 7,0 mg/kg, pakahi).