E kūʻai aku iā Paroxetine-d6 ma ka pūnaewele

Ma hea e kūʻai ai iā Paroxetine-d6 ma ka pūnaewele?

Hōʻike o ka huahana
Hoʻohana ʻia ʻo Paroxetine-d6 ma ke ʻano he maʻamau kūloko no ka helu ʻana o ka paroxetine (Item No. 14998) e ka chromatography gas (GC) a i ʻole ka chromatography-mass spectrometry (LC-MS).

ʻO Paroxetine kahi mea hoʻopaneʻe reuptake serotonin koho (SSRI; Ki = 0,04 nM) .1 He mea koho ia no ka serotonin transporter (SERT) ma luna o ka dopamine a me nā mea lawe norepinephrine (Kis = 400 a me 90 nM, i kēlā me kēia), a me ka serotonin (5-HT) receptor subtypes 5-HT1A a me ka 5-HT2A receptor a me ka 1-HT1A receptor. adrenergic receptors (α2-AR), a me ka muscarinic acetylcholine receptors (mAChR; Kis = 2, 21, 168, 6320, 13, a me 746 nM, kēlā me kēia).

1,2 Paroxetine (5 mg/kg) emi immobility manawa i ka ho'āʻo 'auʻau koi i loko o mice.3 Formulations i loaʻa paroxetine ua hoʻohana 'ia i ka mālama 'ana i ke kaumaha, obsessive-compulsive maʻi (OCD), panic maʻi, ka nohona a me ka generalized anxiety maʻi, a me ka post-traumatic stress disorder (PTSD). ʻike loea

inoa kūhelu
(3S,4R)-3-[(1,3-benzodioxol-5-iloxi)metil-d₂]-4-(4-fluorofenil)-piperidina-2,2,6,6-d₄, monoclorhidrato
ʻAno molekala
C₁₄H₁₂D₆FNO₃•HCl
Kaumaha molekula
371.9

Maʻemaʻe
≥99% nā ʻano i hoʻopau ʻia (d₁-d₄)
Hoʻoponopono
Paʻa
Solubility (E aʻo e pili ana i ka hoʻololi ʻana o ka solubility)
DMF: 33 mg / ml
DMSO: 20 mg / ml
Ethanol: 20 mg/ml
Hoʻouna a mālama ʻike
Kelepili Pono'ī
-20 ° C
Envío
ʻO ka mahana wela ma ka ʻāina ʻAmelika; ʻokoʻa paha ma nā wahi ʻē aʻe
Kūlā
≥4 makahiki
E kūʻai i ka paroxetine-d₁ ma ka pūnaewele