E kūʻai aku iā Sertraline-d3 (hydrochloride) ma ka pūnaewele

Hoʻohana ʻia ʻo Sertraline-d3 ma ke ʻano he maʻamau kūloko no ka helu ʻana o ka sertraline (ikamu helu 14839) e GC a i ʻole LC-MS. ʻO Sertraline he mea hoʻopaneʻe reuptake serotonin koho (SSRI) .1,2 Hoʻopili ia i ka laweʻana o ka monoamine e ka serotonin transporter (SERT) me ka waiwai IC50 o 70 nM.

1 He koho ia no SERT ma nā mea lawe norepinephrine a me dopamine (IC50 = 520 a me 720 nM, kēlā me kēia). Hoʻemi ʻo Sertraline (3,2–56 mg/kg, sc) i ka hiki ʻole i ka hoʻāʻo ʻana i ka ʻauʻau ʻana i nā ʻiole. i loko o nā pūnaewele Vero.

Hiki ke pale ʻia kēia hopena e ka noi exogenous o C16.3 ceramide.XNUMX Ua hoʻohana ʻia nā formulations i loaʻa i ka sertraline i ka mālama ʻana i ke kaumaha, obsessive-compulsive disorder (OCD), premenstrual dysphoric disorder (PMDD), a me nā maʻi hopohopo like ʻole. ʻike loea

inoa kūhelu
(1S,4S)-4-(3,4-diclorofenil)-1,2,3,4-tetrahidro-N-metil-d₃-1-naftalenamina, monoclorhidrato
Helu CAS
1217741-83-7

ʻAno molekala
C₁₄H₁₂Cl₂D₃N • HCl
Kaumaha molekula
345.7
Maʻemaʻe
≥99% nā palapala i hoʻopau ʻia (d₁-d₃)

Ka hoʻopololei
Paʻa A
Solubility
Methanol: hiki ke hoʻoheheʻe
SMILES
ClC(C=C₁)=C(Cl)C=C₁[C@H](CC[C@H]₂NC([2H])([2H])[2H])C₃=C₂C=C₃.Cl
InChi Code
InChI=1S/C₁₄H₁₄Cl₂N.ClH/c₁₄-20-17-9-7-12(13-4-2-3-5-14(13)17)11-6-8-15(18)16(19)10-11;/h₂₄-6,8,10,12,17,20H,7,9H₂,1H₃;1H/t₁₄-,17-;/m₃/s₁/i₂D₃;
InChi Ki
BLFQGGGGFNSJKA-FEGLBNOFSA-N

Hoʻouna a mālama ʻike
Kelepili Pono'ī
-20 ° C
Envío
ʻO ka mahana wela ma ka ʻāina ʻAmelika; ʻokoʻa paha ma nā wahi ʻē aʻe
Kūlā
≥ 4 makahiki
E kūʻai i ka sertraline-d₃