Propoxur-d3 online 5mg

E kūʻai aku iā Propoxur-d3 ma ka pūnaewele

Ke ʻimi nei i kahi e kūʻai ai iā Propoxur-d3 ma ka pūnaewele?
Hoʻohana ʻia ʻo Propoxur-d3 ma ke ʻano he maʻamau kūloko no ka helu ʻana o ka propoxur (ikamu helu 25628) e ke kinoea chromatography (GC) a i ʻole ka wai chromatography-mass spectrometry (LC-MS).

ʻO ka Propoxur he mea hoʻomakeʻa carbamate, acetylcholinesterase inhibitor (IC50 = 4,3 µM) a me ka antagonist o ka nicotinic acetylcholine receptors i loaʻa ka α4β4 subunit (IC50 = 165 µM no ka ʻiole receptor). 1,2 He mea make ia i ka cockroach Kelemania (B. germanica), me nā waiwai LD50 o 2,45, 4,73 a me 1,06 μg i kēlā me kēia pepeke no nā kāne a me nā wahine hou a me nā nymphs 4-wiki. Hoʻoulu ʻo Propoxur i ka hoʻokuʻu ʻana o ka lactate dehydrogenase (LDH) a kāohi i ka ulu ʻana o nā pūpū gill i ka flounder (IC50 = 86,59 a me 89,96 μg / ml, kēlā me kēia) ma o ka hoʻoulu ʻana i ka necrosis.3 Hoʻoulu pū ʻo ia i ka ʻeke yolk a me ka edema pericardial i ka zebrafish embryos o 100μg ke hoʻohana ʻia i ka 200μg embryos o XNUMXμg.

ʻO ka propoxur (8,3 mg/kg) ke kāohi i ke koko a me ka lolo cholinesterase i nā ʻiole, hoʻemi i ka wikiwiki a me ka hānai ʻana ma kahi hoʻāʻo ākea ākea, a hoʻonui i ka latency e pakele ai i ka haʻalulu wāwae ma hope o ka hoʻoulu ʻana i ka pahu hana pale ʻelua i nā ʻiole. ʻIke loea

inoa kūhelu
2-(1-methylethoxy)-phenol 1-(N-methyl-d3-carbamate)
Helu CAS
1219798-56-7
ʻAno molekala
C₁H₁₂D₃NO₃
Kaumaha molekula
212.3
Maʻemaʻe

≥99% nā palapala i hoʻopau ʻia (d₁-d₃)
Hoʻoponopono
Paʻa
Solubility (Loaʻa ka ʻike e pili ana i ka hoʻololi solubility)
DMSO: hoʻoheheʻe iki
Methanol: hiki ke hoʻoheheʻe iki
SMILES
CC(C)OC₁=C(OC(NC([2H])([2H])[2H])=O)C=CC=C₁
InChi Code
InChI=1S/C₁₁H₁₃NO₃/c₁₃ …